Episode: 601 | Aired: September 22, 1990
Blanche's daughter wants to give birth in a birthing center while Blanche is preoccupied by the possibility of Rebecca delivering in a local hospital. Blanche doesn't want to be embarrassed by the fact that her daughter was artificially inseminated.
Episode: 602 | Aired: September 29, 1990
Rose makes a stunning discovery while admitting a patient at the hospital. Meanwhile, Sophia has to have surgery, but a mix-up occurs after the operation and Sophia becomes lost in the hospital. Guest Star: Don Ameche
Episode: 603 | Aired: October 06, 1990
Stan has finally hit it big with a new invention, but still Dorothy can't be happy for him. Meanwhile, Rose and Blanche fight over some war bonds that, if cashed, could bankrupt St. Olaf. Guest Star: Herb Edelman
Episode: 604 | Aired: October 13, 1990
Dorothy decides to help Sophia with the Meals on Wheels program and runs across a reclusive man who hasn't stepped out of his apartment since the 1960's. Meanwhile, Blanche's birthday is coming up and Rose becomes determined to find out her real age.
Episode: 605 | Aired: October 20, 1990
Blanche gets an unexpected visit from her childhood "mammy" (nanny) but Blanche is reluctant to even speak to her since she deserted her when she was a child. Meanwhile, Sophia hires a matchmaker for Dorothy who experiences a date with a convict. Guest Star: Ruby Dee
Episode: 606 | Aired: October 27, 1990
Dorothy receives threats after failing a football star, which means he can't play in an upcoming football game. Meanwhile, Rose must deal with her dentist who she thinks fondled her during her last visit.
Episode: 607 | Aired: November 03, 1990
Dorothy finds herself being wooed by Stan and it seems her old feelings for him are resurfacing. Meanwhile, Rose has to deal with an annoying co-worker. Guest Stars: Herb Edelman, Sibohan Fallon
Episode: 608 | Aired: November 10, 1990
After the death of a friend, who had been a nun, Sophia decides she would like to become one. So she joins a convent and moves out. Meanwhile, Blanche gets into a car accident with Rose's car, which leaves Rose with a lawsuit. Guest Star: Kathleen Freeman
Episode: 609 | Aired: November 17, 1990
Blanche has a secret admirer and is shocked when she meets him: her supposedly dead husband, George. Meanwhile, Dorothy is being wooed by two men, Sonny Bono and Lyle Waggoner. Guest Stars: Sonny Bono, Lyle Waggoner
Episode: 610 | Aired: November 24, 1990
Both Sophia and Rose take advice from Blanche that lands each of them in hot water. Due to a drought in St. Olaf, Rose swears to be celibate and Blanche advises her not to tell Miles the truth. While Sophia takes Blanche's tips to lure a man to bed but when she tells him she loves him, he doesn't respond with what she hoped. Guest Star: Harold Gould
Episode: 611 | Aired: December 01, 1990
Blanche meets a man at the library and only after they make a date does she realize he's in a wheelchair. Meanwhile, Rose wants to keep one of the puppies from Dreyfuss's litter despite Blanche's feelings.
Episode: 612 | Aired: December 15, 1990
Dorothy must give the eulogy at her brother (a cross dresser), Phil's funeral. Meanwhile, a fued between Sophia and Phil's widow reaches a peak leading Sophia to reveal her hidden feelings about her son's alternative lifestyle.
Episode: 613 | Aired: January 05, 1991
Rose wants more adventure in her relationship with Miles, so she signs them up for sky diving lessons. Meanwhile, Blanche's relationship with an abusive man causes Dorothy to speak her feelings. Guest Star: Harold Gould
Episode: 614 | Aired: January 12, 1991
Blanche's gay brother Clayton, makes a visit to Miami with a surprise, he has found the right person to make a commitment to, but Blanche still can't get over Clayton's sexual orientation. Meanwhile, Rose expects to win a Volunteer of the Year award.
Episode: 615 | Aired: January 19, 1991
After hearing that a mobster has died, Miles reveals that he has been in a witness protection program. However, when it is revealed that the mobster faked his death, Miles must leave Miami and go into hiding. Guest Star: Harold Gould
Episode: 616 | Aired: February 02, 1991
Dorothy has been sneaking around so that Sophia doesn't discover that she's been dating Stan. However, when Stan proposes, Dorothy must reveal the truth to Sophia. Guest Star: Herb Edelman
Episode: 617 | Aired: February 09, 1991
Totally against Dorothy and Stan's impending nuptials, Sophia vows to not let the ceremony go off. Meanwhile, Blanche begins interviewing for a new roommate since Dorothy is planning to move out. Guest Star: Herb Edelman, Debbie Reynolds, Marvin Mitchelson
Episode: 619 | Aired: February 16, 1991
Blanche wants to intensify her relationship with her infamous one-night-stand-man, Mel Bushman. Meanwhile, Rose tries her hand at TV reporting. Her assignment: a dog show.
Episode: 618 | Aired: February 16, 1991
Wanting someone to watch after Sophia during the day, Dorothy gets Sophia a job under false pretenses. Meanwhile, Blanche and Rose are all excited about being hired as models for a Penny Saver.
Episode: 620 | Aired: March 02, 1991
While babysitting for her granddaughter, a man mistakes Blanche as being the baby's mother and Blanche does nothing to set him straight. Meanwhile, Sophia gets ready for the Festival of the Dancing Virgins, a celebration of mothers and daughters but Dorothy wants no part of it.
Episode: 621 | Aired: March 09, 1991
Rose has a new man, Carl, in her life but suddenly out of the blue Miles returns, still undercover in the Witness Protection Program. However, things get hairy when Carl reveals himself to be the mobster that is after Miles. Meanwhile, Sophia loses her glasses. Guest Star: Harold Gould
Episode: 622 | Aired: March 23, 1991
The man who stood Dorothy up for her senior prom contacts her and they make a date. After learning why he stood her up, Dorothy unleashes her wrath on the person at fault, Sophia.
Episode: 623 | Aired: April 06, 1991
The girls prepare for the Children's Hospital Bachelorette Auction and a reluctant Dorothy decides to participate. She is in for a quick surprise when Stan walks in and begins bidding. Meanwhile, Sophia's brother, Angelo, comes to Miami, broke and with no place to live. Guest Star: Herb Edelman
Episode: 624 | Aired: April 27, 1991
The deathbed confession of an ex-patient at Shady Pines means bad news for Sophia, since in her confession she stated that she and Sophia started the 1985 Shady Pines fire.
Episode: 625 | Aired: April 27, 1991
Sophia can't remember the events of the evening of the 1985 Shady Pines fire and decides to jump bail and go back to Sicily. With the threat of Sophia going to jail, the girls reminisce about good times they have spent together.
Episode: 626 | Aired: May 04, 1991
Dorothy is in charge of directing a school play, Henny Penny, but when the cast is quarantined, she gets Rose, Blanche, and herself to perform as the leads. But when Rose reads the ending, she wants no part in the play.