Episode: 501 | Aired: September 23, 1989
Dorothy is feeling rundownand tired all the time and has a lack of energy. She is sure she is ill, but all of the doctors she visits tell her she's fine. Meanwhile, Blanche decides to write a romance novel. Guest Star: Jeffrey Tambor
Episode: 502 | Aired: September 30, 1989
Dorothy continues to seek medical advice and turns to Harry Weston for help. Meanwhile, Blanche goes on a writing binge, resulting in a novel that is less then enthralling.
Episode: 503 | Aired: October 14, 1989
Blanche's daughter, Rebecca, has some wonderful news. She's going to become a mother through artificial insemination. However, Blanche is less then thrilled. She's totally against the entire thing.
Episode: 504 | Aired: October 21, 1989
When the company that Rose's husband worked for, cuts off their pension plan, Rose must face the fact that she's going to get a new job, one that pays more. However, she quickly finds herself dealing with something she never expected, age discrimination. Meanwhile, Sophia goes wild buying things in quantity at a Shopper's Warehouse.
Episode: 505 | Aired: October 28, 1989
Dorothy is in a serious relationship with a lawyer and jumps to the conclusion that he's on the verge of proposing. However, his announcement is a shocker: he's leaving law to become a circus clown. Meanwhile, Rose and Blanche put together a protest to save some dolphins. Guest Star: Dick Van Dyke
Episode: 506 | Aired: November 04, 1989
Rose has been dating, Miles Webber, a college professor, but the only thing they seem to have in common is the dance floor. But when Miles invites her to a party, Rose feels like a fish out of water being surrounded by all his intelligent friends. Meanwhile, Blanche battles a dating slump. Guest Star: Harold Gould
Episode: 507 | Aired: November 11, 1989
Sophia's friend has come up with an idea that will change her life. She wants to commit suicide and she wants Sophia there to hold her hand. Meanwhile, Blanche, Rose and Dorothy become singing nursemaids to a sick baby that they are taking care of for the weekend.
Episode: 508 | Aired: November 18, 1989
Blanche is visited by her brother in-law and is taken back by his resemblance to her deceased husband. She quickly finds herself falling in love with hopes of marriage.
Episode: 509 | Aired: November 25, 1989
Dorothy finds a list of things that she wanted to accomplish before a certain age and finds that she hasn't accomplished many of them. So she decides to go after one of them, entertaining people. This leads her to sign up to do a stand up routine at a nightclub. Meanwhile, Blanche finds herself battling the IRS.
Episode: 510 | Aired: December 02, 1989
Dorothy's son, Michael, shows up on her doorstep with news that he's separated with his wife and needs a place to stay. However, Dorothy quickly gets tired of his freeloading and dumps him on Stan. Meanwhile, Rose's stress is getting terrible and is reluctant to talk to her boss about cutting back on her "things-to-do" list. Guest Star: Herb Edelman
Episode: 511 | Aired: December 09, 1989
Blanche is shattered after her father, Big Daddy, passes away. However, when she goes back to her childhood home, she gets into a big argument with her sister, Virginia, and decides not to attend the funeral.
Episode: 512 | Aired: December 16, 1989
It's the Christmas season and the girls are fed up with Christmas shopping in a heat wave. So they decide to buy gifts for the one person they pick from a hat. Later, the girls decide to serve Christmas dinner for the homeless, including a recently homeless Stan. Guest Star: Herb Edelman
Episode: 513 | Aired: January 06, 1990
The girls take in a 15-year-old girl who has just found out she's pregnant and scared to tell her father. Meanwhile, Blanche's prison pen pal has just been released and is looking for her.
Episode: 514 | Aired: January 13, 1990
Rose joins a positive thinking group and tries to get a pessimistic Dorothy to join. Meanwhile, Blanche is scared to get serious with her latest boyfriend, especially after he has a heart attack.
Episode: 515 | Aired: January 27, 1990
Blanche tries to lure men by placing a fake ad in the paper trying to sell a Mercedes. Meanwhile, Rose has to deal with meeting Miles' daughter who makes it clear she wants their relationship to be no more and Dorothy discovers Sophia is hoarding Social Security money, thanks to a computer error. Guest Star: Harold Gould
Episode: 516 | Aired: February 03, 1990
Dorothy becomes alarmed when Sophia forgets the date of her wedding anniversary. This leads Dorothy to face the fact that Sophia is becoming more and more forgetful with age. After visiting a doctor, Sophia decides to regain some of the memories she has lost and decides to take a trip to Brooklyn and their old apartment.
Episode: 517 | Aired: February 10, 1990
After visiting the doctor, Blanche learns that he wants to put a pacemaker in her. However, after the operation, Blanche is so scared of intimacy that she decides to give up sex.
Episode: 518 | Aired: February 12, 1990
Blanche is stunned when a man comes to the front door and claims to be the illegitimate son of her late husband. Meanwhile, Dorothy and Sophia enter a mother-daughter pageant at Shady Pines. Guest Star: Mark Moses
Episode: 519 | Aired: February 17, 1990
Rose discovers that she may be carrying the HIV virus after learning the blood they used in her gallbladder operation may have contained HIV antibodies. What really gets to her though is the 72 hours she must wait before hearing the test results. Meanwhile, Dorothy organizes a Save the Swamplands charity.
Episode: 520 | Aired: February 24, 1990
Rose must decide between her boyfriend, Miles, or an old boyfriend who has just come to town and asks her to go to Europe with him. Meanwhile, fed up with Dorothy's rules, Sophia decides to move out. Guest Star: Harold Gould
Episode: 521 | Aired: March 03, 1990
Blanche and her sister, Charmaine, reconcile after a life-long rivalry. However, the reconciliation does not last long after Blanche reads her recently published book and realizes the heroine is based on her. Meanwhile, Dorothy becomes fed up with Stan's visiting cousin.
Episode: 522 | Aired: March 24, 1990
The married man whom Dorothy once dated re-enters her life and has news that he's now divorced and would like to reconcile with Dorothy. Meanwhile, Blanche and Sophia become the victims of a con game. Guest Star: Jerry Orbach
Episode: 523 | Aired: March 31, 1990
The girls attend the wedding of Dorothy's goddaughter, whose father was once engaged to Sophia. Sophia thinks that the wedding reception is the perfect spot for revenge after supposedly puting a curse on him years ago.
Episode: 524 | Aired: April 28, 1990
Dorothy's gambling problem re-surfaces after a visit to the race track and quickly begins falling in to debt and gaining an apathy to her job. Meanwhile, Rose takes up painting and Blanche is insulted after a man she works with rejects her advances. Guest Star: Michael Ensign
Episode: 525 | Aired: May 05, 1990
An FBI agent investigates the girls' lives for a possible visit from President Bush. This leads the girls to reminisce about times they have spent together. Guest Star: Quentin Tarantino
Episode: 526 | Aired: May 05, 1990
When the FBI agent announces that George Bush will make a visit to their home, the girls continue to reminisce and Dorothy quickly readies a list of points she wants to make to the president. Guest Stars: Herb Edelman, Quentin Tarantino