George Segal was born in Great Neck, New York on February 13, 1934. He began his career not as an actor but as a musician, playing the banjo for Bruno Lynch and the Impressive Jazz Band. He was formerly in the military and attended Columbia University in New York City. Following his graduation in 1955, he became a credited actor.

In 1965, he achieved notoriety for playing David in Ship of Fools. The same year he also played a very memorable Biff Loman in Death of a Salesman. The next year he was nominated for an Oscar for playing Nick in Who’s Afraid of Virginia Wolf opposite Elizabeth Taylor and Richard Burton. More film roles followed, including: The Owl and The Pussycat, Born To Win and The Hot Rock, co-starring Paul Newman. In 1973, he co-starred in A Touch of Class with Glenda Jackson, who won an Oscar. This film placed Segal at the top of the acting game.

In the 1980s, he made his living primarily as a television actor, appearing in shows including Deadly Game, The Cold Room and Murphy’s Law. In 1989, Segal returned to the big screen in the comedy Look Who’s Talking and reprised his role in Look Who’s Talking Now.

In 1993, NBC cast him in what became a part of their "Must See TV" block, Just Shoot Me! During his tenure on the show, he also he leant his voice to the animated Hanna-Barbera Cartoons action adventure television series: The Real Adventures of Johnny Quest as Dr. Quest.

After a successful run with Just Shoot Me! Segal took roles in the films Three Days To Vegas, For The Boys, Flirting With Disaster, The Cable Guy and The Mirror Has Two Faces.

Segal will star in the upcoming comedy Made For Each Other to be released in 2008.