Episode: 099 | Aired: October 06, 1988
Denise announces she will not return to Hillman, while Theo can't get a dorm room at New York University.
Episode: 100 | Aired: October 13, 1988
A nervous Cliff prepares for his annual physical checkup; Denise has trouble at her new job. John Amos guest stars.
Episode: 101 | Aired: October 20, 1988
Rudy holds sway over the house when a friend sleeps over which give Theo trouble as he struggles with a school assignment.
Episode: 102 | Aired: October 27, 1988
The family wants better accommodations for Elvin and expectant Sondra, who doesn't want financial assistance from her family.
Episode: 103 | Aired: November 03, 1988
Vanessa encounters boy trouble; Denise is offered a job as a photographer's assistant.
Episode: 104 | Aired: November 10, 1988
The Huxtables anxiously await the birth of Sondra and Elvin's baby. Naomi Campbell, Kasi Lemmons and Michelle Thomas guest star.
Episode: 105 | Aired: November 10, 1988
The family is shocked to discover that Sondra has given birth to twins; Clair and Cliff try to come to terms with being grandparents. Kasi Lemmons and Naomi Campbell guest star.
Episode: 106 | Aired: November 17, 1988
Theo's plan to get a date through a friend backfires. Rudy attempts to do housework to pay off a debt. Naomi Campbell guest stars.
Episode: 107 | Aired: December 01, 1988
A voice teacher helps Vanessa and her friends polish a musical act. Betty Carter guest stars.
Episode: 108 | Aired: December 08, 1988
Clair hires a fitness instructor to help her fit back into a favorite outfit. FACTOID: Famed choreographer/actress and guest star Debbie Allen is Phylicia Rashad's sister.
Episode: 109 | Aired: December 15, 1988
Rudy is entrusted with the care of a friend's pet hamster, with disastrous results.
Episode: 110 | Aired: January 05, 1989
Theo and Rudy lie for Vanessa so she can go on a date, which gets Vanessa into trouble with her parents.
Episode: 111 | Aired: January 12, 1989
Cliff watches over infants Nelson and Winnie for Sondra and Elvin while the rest of the family goes to a concert.
Episode: 112 | Aired: January 26, 1989
Clair appears on a public affairs TV show, but has difficulty getting the respect of the other panelists. Austin Pendleton guest stars.
Episode: 113 | Aired: February 02, 1989
When Theo has the house to himself he organizes a small gathering which quickly erupts into a wild party.
Episode: 114 | Aired: February 06, 1989
Cliff meets a patient's eccentric grandfather who doubts his abilities as a doctor. Sammy Davis, Jr. and Arnold Stang guest star.
Episode: 115 | Aired: February 09, 1989
Clair and Cliff let Rudy stay up late, but this leads to trouble at school.
Episode: 116 | Aired: February 16, 1989
Lovelorn Theo consults a voodoo doctor. Harold Perrineau Jr. and Moses Gunn guest star.
Episode: 117 | Aired: February 23, 1989
Cliff's basketball squad takes on a team of much younger opponents. Tiger Haynes guest stars.
Episode: 118 | Aired: March 09, 1989
Sondra feels overwhelmed caring for the twins while Elvin is busy with medical school.
Episode: 119 | Aired: March 16, 1989
Theo's girlfriend catches him kissing another woman. FACTOID: The "Vanessa Williams" who guests in this episode is not the former Miss America/recording star/actress of the same name, but rather the Vanessa Williams who also appeared in Candyman and Melrose Place.
Episode: 120 | Aired: March 30, 1989
Cliff tries to ease Clair's 46th birthday blues by inviting his colleague Alberto Santiago over to sing.
Episode: 121 | Aired: April 13, 1989
When Rudy and Vanessa's constant bickering becomes too much for Cliff to bear, hospitality at Hotel Huxtable comes to an abrupt halt.
Episode: 122 | Aired: April 27, 1989
Theo's friends Denny and Jade may do some time when the watch Denny gives to Jade turns out to be stolen.
Episode: 123 | Aired: May 04, 1989
While Sondra is sick and her guard is down, the grandmothers swiftly move in and snatch up the twins.
Episode: 124 | Aired: May 11, 1989
Theo fears his parents will stonewall his request to go on an archaeological dig in Egypt.