Dr. Kelso is the chief of medicine for Sacred Heart Hospital. He always puts the long-term interests of the hospital above those of any individual patient, particularly when it comes to finances. This often creates arguments between him and Dr. Cox. When Kelso is forced to retire, Dr. Cox becomes the new chief.

Kelso is married and often cheats on his wife -- at one point she throws him out of the house when she learns of his affairs. Kelso can be compassionate; however, it's often concealed by his gruff exterior.