Episode 100 - The Physical
A nervous Cliff prepares for his annual physical checkup; Denise has trouble at her new job. John Amos guest stars.

Episode 101 - Rudy's All Nighter
Rudy holds sway over the house when a friend sleeps over which give Theo trouble as he struggles with a school assignment.

Episode 102 - Move It
The family wants better accommodations for Elvin and expectant Sondra, who doesn't want financial assistance from her family.

Episode 103 - Out of Brooklyn
Vanessa encounters boy trouble; Denise is offered a job as a photographer's assistant.

Episode 104 - The Birth, Pt. 1
The Huxtables anxiously await the birth of Sondra and Elvin's baby. Naomi Campbell, Kasi Lemmons and Michelle Thomas guest star.

Episode 105 - The Birth, Pt. 2
The family is shocked to discover that Sondra has given birth to twins; Clair and Cliff try to come to terms with being grandparents. Kasi Lemmons and Naomi Campbell guest star.

Episode 106 - Cyranoise de Bergington
Theo's plan to get a date through a friend backfires. Rudy attempts to do housework to pay off a debt. Naomi Campbell guest stars.

Episode 107 - How Do You Get to Carnegie Hall?
A voice teacher helps Vanessa and her friends polish a musical act. Betty Carter guest stars.

Episode 108 - If The Dress Fits Wear It
Clair hires a fitness instructor to help her fit back into a favorite outfit.

FACTOID: Famed choreographer/actress and guest star Debbie Allen is Phylicia Rashad's sister.

Episode 109 - Is There A Hamster in the House?
Rudy is entrusted with the care of a friend's pet hamster, with disastrous results.

Episode 110 - Truth or Consequences
Theo and Rudy lie for Vanessa so she can go on a date, which gets Vanessa into trouble with her parents.

Episode 111 - Cliff Babysits
Cliff watches over infants Nelson and Winnie for Sondra and Elvin while the rest of the family goes to a concert.

Episode 112 - Mrs. Huxtable Goes to Kindergarten
Clair appears on a public affairs TV show, but has difficulty getting the respect of the other panelists. Austin Pendleton guest stars.

Episode 113 - The Lost Weekend
When Theo has the house to himself he organizes a small gathering which quickly erupts into a wild party.

Episode 114 - No Way Baby
Cliff meets a patient's eccentric grandfather who doubts his abilities as a doctor. Sammy Davis, Jr. and Arnold Stang guest star.

Episode 115 - Can I Say Something, Please?
Clair and Cliff let Rudy stay up late, but this leads to trouble at school.

Episode 116 - The Dead End Kids Meet Dr. Lotus
Lovelorn Theo consults a voodoo doctor. Harold Perrineau Jr. and Moses Gunn guest star.

Episode 117 - The Boys of Winter
Cliff's basketball squad takes on a team of much younger opponents. Tiger Haynes guest stars.

Episode 118 - It Comes and It Goes
Sondra feels overwhelmed caring for the twins while Elvin is busy with medical school.

Episode 119 - Theo's Women
Theo's girlfriend catches him kissing another woman.

FACTOID: The "Vanessa Williams" who guests in this episode is not the former Miss America/recording star/actress of the same name, but rather the Vanessa Williams who also appeared in Candyman and Melrose Place.

Episode 120 - Birthday Blues
Cliff tries to ease Clair's 46th birthday blues by inviting his colleague Alberto Santiago over to sing.

Episode 121 - A Room with No View
When Rudy and Vanessa's constant bickering becomes too much for Cliff to bear, hospitality at Hotel Huxtable comes to an abrupt halt.

Episode 122 - What He Did For Love
Theo's friends Denny and Jade may do some time when the watch Denny gives to Jade turns out to be stolen.

Episode 123 - Day of the Locusts
While Sondra is sick and her guard is down, the grandmothers swiftly move in and snatch up the twins.

Episode 124 - 57 Varieties
Theo fears his parents will stonewall his request to go on an archaeological dig in Egypt.